反应详情

A solution of 1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-carbaldehyde (1.214 g, 5.67 mmol) prepared in Preparation 3 and 4-fluoroaniline (0.54 ml, 5.67 mmol) in ethanol (10 ml) was refluxed for 1 hour. The reaction mixture was cooled to room temperature and then concentrated under reduced pressure to give 2.3 g of the titled compound as a brown solid. The product was used in the subsequent step without further purification.

1. temperaturewas refluxed for 1 hour
2. concentrationconcentrated under reduced pressure