反应详情

Methylmagnesium bromide (3.0M in ethyl ether solution, 37 μl, 1.12 mmol) was added at 0° C. to a solution of N-(1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-ylmethylene)-4-fluorophenylamine (30 mg, 0.112 mmol) prepared in Step 1 in anhydrous ethyl ether (5 ml). The reaction mixture was stirred for 2 hours at room temperature and then a saturated ammonium chloride solution (5 ml) was added thereto. The reaction mixture was extracted with ethyl acetate (15 ml), dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (ethyl acetate/n-hexane=1/1, v/v). The resulting yellow oil was dissolved in ethyl acetate, saturated with hydrochloric acid gas, and then filtered. The resulting solid was dried under reduced pressure to give 1.4 mg of the titled compound as a white solid.

1. extractionThe reaction mixture was extracted with ethyl acetate (15 ml)
2. dry with materialdried on anhydrous magnesium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe resulting residue was purified with silica gel column chromatography (ethyl acetate/n-hexane=1/1
5. dissolutionThe resulting yellow oil was dissolved in ethyl acetate, saturated with hydrochloric acid gas
6. filtrationfiltered
7. customThe resulting solid was dried under reduced pressure