4-Methylbenzylamine → 2,3-dimethyl-7-(4-methylbenzylamino)-1-propyl-1H-pyrrolo[2,3-c]pyridine hydrochloride

HRID 1932343Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH2:14][CH3:15])[C:7]=12.[CH3:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19][CH:18]=1>>[ClH:1].[CH3:12][C:9]1[N:8]([CH2:13][CH2:14][CH3:15])[C:7]2=[C:2]([NH:22][CH2:21][C:20]3[CH:23]=[CH:24][C:17]([CH3:16])=[CH:18][CH:19]=3)[N:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[CH3:11]

Participants

Reactant 2

HCID 660354-Methylbenzylamine

HCID 11701344HCID 11701344, compound

Product 1

HCID 671409672,3-dimethyl-7-(4-methylbenzylamino)-1-propyl-1H-pyrrolo[2,3-c]pyridine hydrochlorideYield 35%

Procedure

In accordance with the same procedures as in Step 3 of Example 198, except for using 7-chloro-2,3-dimethyl-1-propyl-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 and 4-methylbenzylamine, the titled compound was obtained as a white solid. (Yield: 35%)

Sources & evidence

ORD record: ord-719549e5050146528ddd13c8f75e0a08
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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