4-Methylbenzylamine → 1-allyl-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochloride

HRID 1932345Notes

Reaction equation

[CH2:1]([N:4]1[C:8]2=[C:9]([Cl:13])[N:10]=[CH:11][CH:12]=[C:7]2[C:6]([CH3:14])=[C:5]1[CH3:15])[CH:2]=[CH2:3].[CH3:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19][CH:18]=1>>[ClH:13].[CH2:1]([N:4]1[C:8]2=[C:9]([NH:22][CH2:21][C:20]3[CH:23]=[CH:24][C:17]([CH3:16])=[CH:18][CH:19]=3)[N:10]=[CH:11][CH:12]=[C:7]2[C:6]([CH3:14])=[C:5]1[CH3:15])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 660354-Methylbenzylamine

HCID 11680159HCID 11680159, compound

Product 1

HCID 671415661-allyl-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochlorideYield 29%

Procedure

In accordance with the same procedures as in Step 3 of Example 198, except for using 1-allyl-7-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 and 4-methylbenzylamine, the titled compound was obtained as a white solid. (Yield: 29%)

Sources & evidence

ORD record: ord-afffb46abe184668804f3fec3f561795
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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