2-(4-Chlorophenyl)-3-nitropyridine → HCID 67141227, compound

HRID 1932350Notes

Reaction equation

HRID 1932350 reaction equation
[N+:1]([C:4]1[C:5]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[C:17]([Mg]Br)([CH3:19])=[CH2:18]>>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:5]2[N:6]=[CH:7][CH:8]=[C:9]3[CH:18]=[C:17]([CH3:19])[NH:1][C:4]=23)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 27638662-(4-Chlorophenyl)-3-nitropyridineHCID 178456138HCID 178456138, compound

Product 1

HCID 67141227HCID 67141227, compoundYield 32%

Procedure

In accordance with the same procedures as in Example 242, except for using 3-nitro-2-(4-chlorophenyl)pyridine prepared in Preparation 12 and isopropenylmagnesium bromide, the titled compound was obtained as a white solid. (Yield: 32%)

Sources & evidence

ORD record
ord-d4254a8914a94b7f8363295530044b2c
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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