3-Nitro-2-phenylpyridine → 2-methyl-7-phenyl-1H-pyrrolo[2,3-c]pyridine

HRID 1932351Notes

Reaction equation

HRID 1932351 reaction equation
[N+:1]([C:4]1[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[C:16]([Mg]Br)([CH3:18])=[CH2:17]>>[CH3:18][C:16]1[NH:1][C:4]2=[C:5]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:6]=[CH:7][CH:8]=[C:9]2[CH:17]=1

Participants

3

Reactant 2

HCID 27627873-Nitro-2-phenylpyridineHCID 178456138HCID 178456138, compound

Product 1

HCID 671424892-methyl-7-phenyl-1H-pyrrolo[2,3-c]pyridineYield 37%

Procedure

In accordance with the same procedures as in Example 242, except for using 3-nitro-2-phenylpyridine prepared in Preparation 15 and isopropenylmagnesium bromide, the titled compound was obtained as a white solid. (Yield: 37%)

Sources & evidence

ORD record
ord-cd467bceec394441ae8431bf8f42616f
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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