3-Fluorobenzyl chloride → HCID 86615266, compound

HRID 1932406Notes

Reaction equation

HRID 1932406 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:20]([CH3:21])=[C:19]([CH3:22])[NH:18][C:5]2=[C:6]([N:8]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH3:9])[N:7]=1.[F:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27]Cl>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:20]([CH3:21])=[C:19]([CH3:22])[N:18]([CH2:27][C:26]3[CH:29]=[CH:30][CH:31]=[C:24]([F:23])[CH:25]=3)[C:5]2=[C:6]([N:8]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[CH3:9])[N:7]=1

Participants

3

Reactant 2

HCID 99743-Fluorobenzyl chlorideHCID 86615267HCID 86615267, compound

Product 1

HCID 86615266HCID 86615266, compoundYield 69%

Procedure

In accordance with the same procedures as in Example 657, except for using N-(5-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-(4-fluorobenzyl)-methylamine prepared in Step 1 and 3-fluorobenzyl chloride, the titled compound was obtained as a pale yellow solid. (Yield: 69%)

Sources & evidence

ORD record
ord-1b1f43507e1349dc98ff6a63fed53f4c
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

Loading…