HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → HCID 87485026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Reactant | HCID 68523649 | HCID 68523649 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 87485026 | HCID 87485026 | — |
Reaction Steps
Ethyl 4-(5-aminopyridin-2-yloxy)benzoate (16.0 g, 62 mmol) was dissolved in toluene (300 mL). To the resulting solution were added 4-trifluoromethylacetophenone (11.7 g, 62 mmol) and (±)-camphor-10-sulfonic acid (1.08 g, 4.65 mmol), and refluxed overnight. The reaction solution was concentrated under reduced pressure, to thereby yield 26.5 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188277B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3601c2588faf4365a54b6744ad152ee1 |
| Source note | uspto-grants-2012_05 |