HCID 68522204, compound → HCID 68525767, compound

HRID 1932471Notes

Reaction equation

HRID 1932471 reaction equation
C(OC([N:11]([CH2:32][CH2:33][O:34][CH3:35])[C:12]1[CH:13]=[CH:14][C:15]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][CH:20]=2)=[N:16][CH:17]=1)=O)C1C=CC=CC=1>C(O)C.C(OCC)(=O)C.[C].[Pd]>[CH3:35][O:34][CH2:33][CH2:32][NH:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][CH:20]=2)=[N:16][CH:17]=1

Participants

4

Reactant 1

HCID 68522204HCID 68522204, compound

Product 1

HCID 68525767HCID 68525767, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

To a solution of ethyl 3-(4-{5-[benzyloxycarbonyl(2-methoxyethyl)amino]pyridin-2-yloxy}phenyl}propionate (1.82 g, 3.8 mmol) in ethanol-ethyl acetate (10 mL-10 mL) was added under a nitrogen atmosphere 10% palladium-carbon (0.2 g), and the resulting solution was stirred for 3 hours under a hydrogen atmosphere at atmospheric pressure. The palladium-carbon was filtered off through Celite, and the filtrate was evaporated to yield 1.23 g of the title compound.

Workup

  1. filtrationThe palladium-carbon was filtered off through Celite
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-aafa69cb367a433f9cffb1430f8db573
Source dataset
uspto-grants-2012_05
Patent number
US08188277B2

Reaction notes

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