HCID 68569061, compound → HCID 86761574, compound

HRID 1932493Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]3OCC[O:22]3)=[CH:17][CH:16]=2)=[C:10]([F:26])[CH:9]=1)=[O:6]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]=[O:22])=[CH:17][CH:16]=2)=[C:10]([F:26])[CH:9]=1)=[O:6]

Participants

Conditions

Temperature: 80 °C

Procedure

3,4-Dichloro-N-[4-(4-[1,3]dioxolane-2-ylphenoxy)-3-fluorophenyl]benzamide (17.4 g, 38.9 mmol) was added to 80% acetic acid, and the resulting solution was stirred for 1.5 hours at 80° C. The reaction solution was concentrated under reduced pressure, wherein the obtained residue was recrystallized from 80% ethanol to thereby yield 12.8 g of the title compound.

Workup

concentrationThe reaction solution was concentrated under reduced pressure, wherein the obtained residue
customwas recrystallized from 80% ethanol to thereby yield 12.8 g of the title compound

Sources & evidence

ORD record: ord-c1427fd15dc74d81bcfc5217d0665f25
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188277B2

Reaction notes

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