反应详情

To a solution of N-{6-[4-(piperazine-1-carbonyl)phenoxy]-pyridin-3-yl}-4-trifluoromethyl-benzamide (430 mg, 0.91 mmol) in methanol was added 1,2-epoxycyclohexane (180 mg, 1.83 mmol), and the resulting solution was stirred for 1 day under reflux. The resulting reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol=35:1), and then ethyl acetate was added. The precipitated white powder was filtered off and washed with ethyl acetate, to thereby yield 284 mg of the title compound.

1. temperatureunder reflux
2. customThe resulting reaction solution
3. concentrationwas concentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (chloroform:methanol=35:1)
5. additionethyl acetate was added
6. filtrationThe precipitated white powder was filtered off
7. washwashed with ethyl acetate