反应详情

温度

25 °C

A mixture of (S)-4-(t-butyl-dimethyl-silanyloxy)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-butyric acid methyl ester (250 mg, 0.57 mmol) in a 1:1 solution of tetrahydrofuran:water (8 mL) was treated with lithium hydroxide monohydrate (48 mg, 1.14 mmol) and stirred for 1.5 h at 25° C. After such time, the mixture was concentrated in vacuo to remove the tetrahydrofuran and diluted with water (10 mL) and the pH adjusted to pH=5 with 1N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layers were then dried and concentrated in vacuo to afford (S)-4-(t-butyl-dimethyl-silanyloxy)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-butyric acid (195 mg, 81%) as an off-white foam: HR-ES-MS m/z calculated for C20H28NO5ClSi [M+H]+ 426.1498, observed 426.1498.

1. concentrationAfter such time, the mixture was concentrated in vacuo
2. customto remove the tetrahydrofuran
3. additiondiluted with water (10 mL)
4. extractionextracted with ethyl acetate
5. customThe organic layers were then dried
6. concentrationconcentrated in vacuo