HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1933403Generated: October 30, 2026
1-Bromo-2-fluorobenzene → 5-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile
https://huagongshe.com/reaction/1933403
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-2-fluorobenzene | HCID 61259 | — |
| Reactant | 1-Methyl-1H-imidazole-4-carbonitrile | HCID 2795115 | — |
| Reagent | Cesium acetate | HCID 5152919 | — |
| Catalyst | Palladium, di-mu-chlorobis(eta3-2-propenyl)di- | HCID 61538 | — |
| Catalyst | 2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine | HCID 121237783 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | 4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl | HCID 74195 | — |
| Product | 5-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile | HCID 84117446 | 22.08% |
| Internal standard | 4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl | HCID 74195 | — |
Provenance & Evidence
| Source dataset | Shields Arylation |
|---|
| ORD ID | ord-8918b1dcb42e4c4dbfd4ef382e60060b |
|---|
| Source note | Shields Arylation |
|---|
