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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1933596Generated: October 29, 2026

1-Bromo-2-fluorobenzene → 5-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile

https://huagongshe.com/reaction/1933596

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-fluorobenzeneHCID 61259—
Reactant1-Methyl-1H-imidazole-4-carbonitrileHCID 2795115—
ReagentCesium acetateHCID 5152919—
CatalystPalladium, di-mu-chlorobis(eta3-2-propenyl)di-HCID 61538—
CatalystBis(3,5-bis(trifluoromethyl)phenyl)(3,6-dimethoxy-2',4',6'-tri(propan-2-yl)(1,1'-biphenyl)-2-yl)phosphaneHCID 44597232—
SolventP-XyleneHCID 7809—
Product4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—
Product5-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrileHCID 841174467.15%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature105 °C

Provenance & Evidence

Source datasetShields Arylation
ORD IDord-daf5da14c64045649c19f2a12c0c3852
Source noteShields Arylation