反应详情

温度

25 °C

A mixture of 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4,4,4-trifluoro-butyric acid methyl ester (212 mg, 0.58 mmol) in a 1:1 solution of tetrahydrofuran:water (8 mL) was treated with lithium hydroxide monohydrate (55 mg, 1.16 mmol) and stirred for 1.5 h at 25° C. After such time, the mixture was concentrated in vacuo to remove the tetrahydrofuran and then diluted with water (10 mL) and the pH adjusted to pH=4 with 1N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layers were then dried over sodium sulfate and concentrated in vacuo to afford 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4,4,4-trifluoro-butyric acid (149 mg, 73%) as a white solid: HR-ES-MS m/z calculated for C14H11NO4ClF3 [M+Na]+ 372.0221, observed 372.0224.

1. concentrationAfter such time, the mixture was concentrated in vacuo
2. customto remove the tetrahydrofuran
3. additiondiluted with water (10 mL)
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layers were then dried over sodium sulfate
6. concentrationconcentrated in vacuo