HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 3-Phenylprop-2-enoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2-Propenoic acid, 3-phenyl- | HCID 8784 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Piperidine | HCID 8082 | — |
| Product | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
Reaction Steps
A cinnamic acid is first prepared by reacting a benzaldehyde with malonic acid in pyridine and piperidine. The cinnamic acid is then reacted with thionyl chloride to produce a cinnamoyl chloride derivative. The PECN is finally synthesized by reacting PECN with the cinnamoyl chloride derivative in an inert solvent (such as chloroform, nitrobenzene, chlorobenzene, or the like). The reaction mixture is diluted with methanol, filtered, dried in a vacuum, and milled by a vibrating mill, whereupon the PECN is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06383579B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-a512dc50fe9241ae8c631ac76a91ce3d |
| Source note | uspto-grants-2002_05 |