HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1934311Generated: November 2, 2026
Nitric Acid → 2-(4-Chloro-2-fluoro-5-hydroxy-6-nitrophenyl)-3-chloro-5-trifluoromethylpyridine
https://huagongshe.com/reaction/1934311
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2-Chloro-5-(3-chloro-5-trifluoromethylpyrid-2-yl)-4-fluorophenol | HCID 11823568 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-(4-Chloro-2-fluoro-5-hydroxy-6-nitrophenyl)-3-chloro-5-trifluoromethylpyridine | HCID 22466145 | 79% |
Reaction Steps
0.24 ml (5.8 mmol) of 100% strength nitric acid was added to 1.9 g (5.8 mmol) of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine in 50 ml of concentrated sulfuric acid. The reaction mixture was stirred at about 20° C. for 10 hours and then poured into 100 ml of ice-water. The solids were subsequently removed and dried at 40° C. in a vacuum drying cabinet. Yield: 79%; m.p.: 67-72° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06383986B1 |
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| Source dataset | uspto-grants-2002_05 |
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| ORD ID | ord-e1b7ff752b334c3abddc71e5f62eddf9 |
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| Source note | uspto-grants-2002_05 |
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