Potassium Carbonate → HCID 86758047, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Compound B (700 mg, 2.0 mmol) in anhydrous dichloromethane (50 ml) under nitrogen at 0° C., was added 3-chloroperoxybenzoic acid (666 mg, 2.2 mmol) slowly. The resulting solution was allowed to stir for 2 hours at 0° C. and for 0.5 hour at room temperature. To the resulting clear solution potassium carbonate (415 mg, 3.0 mmol) was added, and the reaction mixture was stirred for 0.75 hour. The white precipitate was removed by filtration. The crude product was purified by flash silica gel chromatography (MeOH-CH2Cl2, 10:90 v/v containing 1% NH4OH). After drying, 505 mg of 2-(4-fluorophenyl)-5-(N-ethylpiperidin-4-yl)-3-(4-pyridyl)pyrrole N-oxide was obtained. NMR (CD3OD)σ8.26(d, J=6.27 Hz, 2H), 7.35(m, 2H), 7.26(d, J=6.13 Hz, 2H), 7.11(m, 2H), 6.28(s, 1H), 3.35(m, 6H), 2.85(m, 1H), 2.46(m, 2H), 2.00(m, 2H), 1.39(t, J=7.10 Hz, 3H); MS(ESI)=366.3

Provenance & Evidence