Azidotrimethylsilane → HCID 53648826, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-tert-butyldimethylsilyl-4(S)-ethynyl-2-azetidinone (3.0 g) and trimethylsilylazide (15 ml) was heated at 80° C. for 20 hours. The reaction mixture was allowed to room temperature and evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with n-hexane ethyl acetate=(1:1) to give 1-tert-butyldimethylsilyl-4(S)-(2H-1,2,3-triazol-4-yl)-2-azetidinone (0.3 g, 8.3%) as a pale yellow solid.

Provenance & Evidence