Ethanol hydrochloride → HCID 86758024, compound

HRID 1934383Notes

Reaction equation

HRID 1934383 reaction equation
[Si]([N:8]1[C@H:11]([C:12]2[CH:16]=[N:15][NH:14][N:13]=2)[CH2:10][C:9]1=[O:17])(C(C)(C)C)(C)C.[ClH:18].[CH3:19][CH2:20][OH:21]>>[ClH:18].[CH2:20]([O:21][C:9](=[O:17])[CH2:10][C@@H:11]([C:12]1[CH:16]=[N:15][NH:14][N:13]=1)[NH2:8])[CH3:19]

Participants

3

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 53648826HCID 53648826, compound

Product 1

HCID 86758024HCID 86758024, compoundYield 94.4%

Procedure

1-tert-Butyldimethylsilyl-4(S)-(2H-1,2,3-triazol-4-yl)-2-azetidinone (0.3 g) was added to 6N HCl/EtOH (10 ml). The mixture was stirred for 1 hour, and then evaporated in vacuo. The crystalline solid was washed with diethyl ether to give 3(S)-(2H-1,2,3-triazol-4-yl)-β-alanine ethyl ester hydrochloride (0.25 g, 94.4%) as a white solid.

Workup

  1. customevaporated in vacuo
  2. washThe crystalline solid was washed with diethyl ether

Sources & evidence

ORD record
ord-52c587b0202940c391ad24175739e362
Source dataset
uspto-grants-2002_05
Patent number
US06384028B1

Reaction notes

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