Hydrochloric Acid → HCID 70092694, compound

Participants

Reaction Steps

To a solution of N-[(R)-1-[3-(1-tert-butoxycarbonyl-4-piperidyl)-(E)-acryloyl]-3-piperidylcarbonyl]-2-hydroxymethyl-β-alanine (0.24 g) in ethyl acetate (2 ml) was added 4N HCl in ethyl acetate (1.3 ml) at 0° C., and the reaction mixture was stirred for 2 hours at room temperature. The precipitates were filtered and washed with diethyl ether to give N-[(R)-1-[3-(4-piperidyl)-(E)-acryloyl]-3-piperidylcarbonyl]-2-hydroxymethyl-β-alanine hydrochloride (0.17 g, 82.0%).

Provenance & Evidence