Trifluoroacetic acid → HCID 70097003, compound

Participants

Reaction Steps

Trifluoroacetic acid (3 ml) was added to N-[(R)-1-[3-(1-tert-butoxycarbonyl-4-piperidyl)propanoyl]-3-piperidylcarbonyl]-3(S)-acetylaminomethyl-β-alanine tert-butyl ester. The solvent was evaporated in vacuo. The residue was neutralized with saturated aqueous NaHCO3 and purified by HP-20 resin eluting with isopropanol/water (0-50% to give N-[(R)-1-[3-(4-piperidyl)propanoyl]-3-piperidylcarbonyl]-3(S)-acetylaminomethyl-β-alanine (120 mg, 50.0%).

Provenance & Evidence