Ethanol → HCID 178435407, compound

Participants

Reaction Steps

To a slurry of 3.95 g (15.3 mmol) of 6-amino-5-(2-ethyl-1,3-dioxolan-2-ylmethyl)-2-thiouracil, 27 mL of ethanol, 3 mL of water and 3.06 mL of 5 M sodium hydroxide was added 1.93 g (15.3 mmol) of methyl sulfate. The reaction exothermed to 45° C. and became a solution. After stirring for 6 hours at ambient temperature, the precipitate was collected by filtration. The solids were washed with 15 mL of water and dried in vacuo (40° C., 10 torr) to yield 2.78 g (67%) of 2-(methylthio)-6-amino-5-(2-ethyl-1,3-dioxolan-2ylmethyl)-4-pyrimidinol as a white powder. nmr (500 MHz, dmso-d6) δ0.80 (t, J=7.4 Hz, 3H), 1.52 (q, J=7.4 Hz, 2H), 2.42 (s, 3H), 2.58 (s, 2H), 3.82 (m, 2H), 3.92 (m, 2H), 6.10 (s, 2H), 11.6 (bs, 1H)

Provenance & Evidence