Hydrochloric Acid → HCID 178435423, compound

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Reaction Steps

The 2-(methylthio)-6-amino-5-(2-ethyl-1,3-dioxolan-2ylmethyl)-4-pyrimidinol (2.50 g, 9.21 mmol) was combined with 69 mL of 0.2 M HCl and stirred at ambient temperature for 18 hours. The solids were collected by filtration, washed with 20 mL of water and dried in vacuo (40° C., 10 torr) to provide a quantitative yield of 1,7-dihydro-6-ethyl-2-(methylthio)-4H-pyrrolo[2,3-d]pyrimidin-4-one as a white solid. nmr (500 MHz, dmso-d6) δ1.17 (t, J=7.5 Hz, 3H), 2.49 (s, 3H), 2.55 (q, J=7.5 Hz, 2H), 6.03 (s, 1H), 11.61 (s, 1H), 11.95 (s, 1H)

Provenance & Evidence