HCID 69558084, compound → HCID 69557385, compound

Participants

Reaction Steps

A suspension of 211 mg (0.541 mmol) of [[2-(methylthio)-6-ethyl-7-[(3-fluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester in 20 mL of ethanol was treated with 1.27 g of Raney Ni and heated to reflux. After 24 hours, the solids were removed by filtration through a filter aid and the reaction concentrated to provide 140 mg (75%) of [[6-ethyl-7-[(3-fluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester as a solid. nmr (300 MHz, CDCl3) δ1.20 (t, 3H), 2.62 (q, 2H), 3.79 (s, 3H), 5.09 (s, 2H), 5.45 (s, 2H), 6.42 (s, 1H), 6.72 (d, 1H), 6.82 (d, 1H), 6.93 (dt, 1H), 7.26 (dt, 1H), 8.37 (s, 1H)

Provenance & Evidence