Hydrochloric Acid → HCID 69557550, compound

Participants

Reaction Steps

A mixture of 28 mg (0.067 mmol) of [[5-(aminooxoacetyl)-6-ethyl-7-[(3-fluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester and 5 mL of methanol were treated with 0.05 mL of 2 M sodium hydroxide and stirred at ambient temperature for 22 hours. The reaction was adjusted to pH 3 by the addition of 1 M HCl and concentrated to provide 10 mg (40%) of [[5-(aminooxoacetyl)-6-ethyl-7-[(3-fluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid as a white solid. nmr (300 MHz, dmso-d6) δ1.02 (t, 3H), 2.94 (q, 2H), 4.91 (s, 2H), 5.59 (s, 2H), 6.90 (d, 1H), 7.04 (d, 1H), 7.10 (dt, 1H), 7.36 (dt, 1H), 7.60 (br s, 1H), 8.02 (br s, 1H), 8.45 (s, 1H)

Provenance & Evidence