Sodium Hydroxide → HCID 69557311, compound

Participants

Reaction Steps

A mixture of 66 mg (0.129 mmol) of [[2-(methylthio)-5-(aminooxoacetyl)-6-ethyl-7-[[3-(trifluoromethyl)phenyl]-methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester and 10 mL of methanol was treated with 0.10 mL of 2 M sodium hydroxide and stirred at reflux for 4 hours. The reaction was cooled to ambient temperature. The product precipitated upon addition of 1 M HCl and was collected by filtration. The solids were dried in vacuo to provide 50 mg (79%) of [[2-(methylthio)-5-(aminooxoacetyl)-6-ethyl-7-[[3-(trifluoromethyl)phenyl]methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid as a solid. nmr (300 MHz, dmso-d6) δ0.99 (t, 3H), 2.36 (s, 3H), 2.82 (q, 2H), 4.86 (s, 2H), 5.62 (s, 2H), 6.48 (d, 1H), 7.51 (m, 2H), 7.64 (s, 1H), 7.84 (d 1H), 8.05 (s, 1H)

Provenance & Evidence