HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 131722148, compound → 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 131722148 | HCID 131722148 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid | HCID 28710109 | — |
Reaction Steps
A 100 mL Fisher/Porter vessel was charged with benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate in 15 mL MeOH with a catalytic amount of 10% Pd—C. Hydrogenation at 50 psi for 48 hours afforded, after filtration through Celite and concentration in vacuo to yield 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid as a hygroscopic foam suitable for use without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384036B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-83d6d64fc01840869285568d4019814e |
| Source note | uspto-grants-2002_05 |