HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1934469Generated: October 26, 2026
Benzhydrylamine → methyl 3-[N-(diphenylmethyl) aminosulfonyl]-2(R)-methylpropionate
https://huagongshe.com/reaction/1934469
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzhydrylamine | HCID 7036 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | methyl 3-chlorosulfonyl-2(R)-methylpropionate | HCID 18738451 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl 3-[N-(diphenylmethyl) aminosulfonyl]-2(R)-methylpropionate | HCID 18738453 | 66.4% |
Reaction Steps
A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1 g aminodiphenylmethane, 2 mL triethylamine in 20 mL CH2Cl2. The reaction was cooled to 0° C. and 1 g of methyl 3-chlorosulfonyl-2(R)-methylpropionate was slowly added. The reaction was stirred 1 hour then concentrated in vacuo. The residue was partioned between ethyl acetate and water. The organic phase was washed with brine, dried, and concentrated in vacuo. Trituration from Et2O/hexanes gave 1.15 g of methyl 3-[N-(diphenylmethyl)aminosulfonyl]-2(R)-methylpropionate as a white solid. HRMS (M+Li): calcd. 354.1351, obs 354.1569.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06384036B1 |
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| Source dataset | uspto-grants-2002_05 |
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| ORD ID | ord-0802d587c64e40aab0e38e558a008d9e |
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| Source note | uspto-grants-2002_05 |
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