Potassium sodium tartarate → HCID 22467287, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (6.12 g) in THF (450 ml) was dropwise added a solution of crude 5-(tert-butyldiphenylsilyloxy)-1-trimethylsilyloxy-1,2,3,4-tetrahydronaphthalene-1-carbonitrile (40.3 g) in THF (300 ml) at 5° C. The mixture was stirred at the same temperature for 1 hour and then at room temperature for 2 hours. The mixture was added with a saturated potassium sodium tartrate solution under ice cooling. A resultant insoluble material was removed by filtration and washed with THF. The filtrate was evaporated to give 1-aminomethyl-5-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ol (34.8 g) as an oil.

Provenance & Evidence