HCID 86758055, compound → HCID 57168096, compound

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Reaction Steps

To a solution of a mixture of ethyl {[6-(N,N-diphenyl-carbamoyloxy)methyl-5,6-epoxy-6,7,8,9-tetrahydro-5H-benzo-cyclohepten-5-yl]oxy}acetate and ethyl {[6-(N,N-diphenyl-carbamoyloxy) methyl-6,7-epoxy-6,7,8,9-tetrahydro-5H-benzo-cyclohepten-1-yl]oxy}acetate (265 mg) in EtOAc (13 ml) was added 10% Pd—C (wet) (80 mg). The mixture was stirred under hydrogen atmosphere at room temperature for 6 hours. After removal of the catalyst by filtration, the filtrate was evaporated. The residue was purified by silica gel column chromatography (hexane-EtOAc 2:1 to 1:1) to give ethyl {[6-(N,N-diphenylcarbamoyloxy)methyl-6-hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yl]oxy}acetate (193.3 mg) as a solid and ethyl {[6-(N,N-diphenylcarbamoyloxy) methyl-6,7-epoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yl]oxy}acetate (60.0 mg) as an oil.

Provenance & Evidence