Sodium Hydroxide → HCID 86758061, compound

Participants

Reaction Steps

To a solution of ethyl {[(5SR,6SR)-6-(N,N -diphenylcarbamoyloxy)methyl-5,6-dihydroxy-6,7,8,9-tetrahydro -5H-benzocyclohepten-1-yl]oxy}acetate (70 mg) in a mixture of MeOH and 1,4-dioxane (1:1, 4 ml) was added 1N sodium hydroxide solution (0.138 ml) at 5° C. The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated followed by addition of Et2O. The resulting solid was collected by filtration to give sodium {[(5SR,6SR)-6-(N,N -diphenylcarbamoyloxy)methyl-5,6-dihydroxy-6,7,8,9-tetrahydro -5H-benzocyclohepten-1-yl]oxy}acetate (65.8 mg).

Provenance & Evidence