Formaldehyde → HCID 53746566, compound

Participants

Reaction Steps

After 37% formalin (0.088 ml, 1.08 mmol) was added to a mixture of 3-oxo-1-indanecarboxylic acid (191 mg, 1.08 mmol) and piperidine (92.3 mg, 1.08 mmol), the mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated. Ethanol (3 ml) and N-acetyl-L-cysteine methyl ester (80 mg, 0.45 mmol) were added to the residue. The mixture was heated to reflux for 10 minutes and then concentrated in vacuo. The residue was purified by silica gel column chromatography (100 ml, chloroform:methanol:acetic acid=30:1:0.5) to give Compound (6A) (62 mg, yield: 15.7%).

Provenance & Evidence