反应详情

温度

140 °C

A solution of 2-[2-(2-chloro-phenoxy)-3-ethoxycarbonyl-allylamino]-5,5,5-trifluoro-4-methyl-pentanoic acid methyl ester (726 mg, 1.66 mmol) in acetonitrile (5 mL) was placed in a sealed microwave reaction tube and heated in a microwave reactor at 140° C. for 2.5 h. The mixture was then concentrated in vacuo and purified by AnaLogix IntelliFlash flash chromatography (12 g column, 10% ethyl acetate/hexanes to 40% ethyl acetate/hexanes) which afforded 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-5,5,5-trifluoro-4-methyl-pentanoic acid methyl ester (379 mg, 58%) as a yellow oil.

1. concentrationThe mixture was then concentrated in vacuo
2. custompurified by AnaLogix IntelliFlash flash chromatography (12 g column, 10% ethyl acetate/hexanes to 40% ethyl acetate/hexanes) which