HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | L-N-Cbz-3-N-Boc-Amino-alanine | HCID 2756240 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate | HCID 10831821 | 104.7% |
Reaction Steps
Iodomethane (554 mg) was added to a suspension of (S)-2-(benzyloxycarbonylamino)-3-(tert-butoxycarbonylamino)propionoic acid (1.1 g) and potassium carbonate (539 mg) in N,N-dimethylformamide (7 mL). The mixture was stirred for 2 hours at ambient temperature and partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give methyl (S)-2-(benzyloxycarbonylamino)-3-(tert-butoxycarbonylamino)propionate (1.2 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384080B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-147f9dac545f4dd5b5e126346e0bc979 |
| Source note | uspto-grants-2002_05 |