Methanol → HCID 178501209, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of cis-4-aminocyclohexanecarboxylic acid (1.04 g) in methanol (25 mL) was added thionyl chloride (0.583 mL) under ice-water cooling. The mixture was stirred for an hour at 0° C. and for 17 hours at ambient temperature. After evaporation of the solvent, the residue was triturated with diethyl ether to give methyl cis-4-aminocyclohexanecarboxylate hydrochloride as white powders (1.37 g).

Provenance & Evidence