Hydrochloric Acid → 2-[4-(2-Chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-5,5,5-trifluoro-4-methyl-pentanoic acid

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Reaction Conditions

Reaction Steps

In a flask was placed 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-5,5,5-trifluoro-4-methyl-pentanoic acid methyl ester (614 mg, 1.56 mmol) dissolved in tetrahydrofuran (10 mL). To this mixture at 25° C. was added a solution of lithium hydroxide monohydrate (131 mg, 3.13 mmol) in water (10 mL). The mixture was then stirred for 2 h at 25° C. After such time, the mixture was treated with a 1N aqueous hydrochloric acid solution until pH=2 and extracted with ethyl acetate (3×20 mL). The organics were combined and dried over magnesium sulfate, filtered and concentrated in vacuo to afford 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-5,5,5-trifluoro-4-methyl-pentanoic acid (575 mg, 98%) as a yellow-orange solid.

Provenance & Evidence