2H-3,1-Benzoxazine-2,4(1H)-dione, 6-nitro- → 2-Amino-N-[(2-chlorophenyl)methyl]-5-nitrobenzamide

Participants

Reaction Steps

To a suspension of 5-nitroisatoic anhydride (300 mg) in dimethylformamide (4 mL) was added 2-chlorobenzylamine (245 mg), and the mixture was stirred for 15 hours at ambient temperature. The mixture was partitioned between ethyl acetate and water. The separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with diisopropyl ether to give 2-amino-N-(2-chlorobenzyl)-5-nitrobenzamide as yellow powders (397 mg).

Provenance & Evidence