HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethylaniline → 2-Chloro-5,6,7,8-tetrahydroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethylaniline | HCID 7061 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5,6,7,8-Tetrahydro-2(1H)-quinazolinone | HCID 178517550 | — |
| Product | 2-Chloro-5,6,7,8-tetrahydroquinazoline | HCID 12933876 | — |
Reaction Steps
A solution of 1 g of 2-hydroxy-5,6,7,8-tetrahydroquinazoline and 0.1 g of diethylaniline in 10 mL of phosphorus oxychloride is refluxed for 2 h, and subsequently cooled and concentrated. The residue is taken up in chloroform and washed with excess 3 N NaOH solution. The organic layer is dried and concentrated to provide 2-chloro-5,6,7,8-tetrahydroquinazoline (1.1 g) as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384224B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-8bd56e60ba6e480f95ba9e39535a70b0 |
| Source note | uspto-grants-2002_05 |