Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → [1-(triphenylmethyl)-1H-imidazol-4-yl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Trityl chloride | HCID 6456 | — |
| 반응물 | (1H-imidazol-2-yl)methanol hydrochloride | HCID 2776278 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | [1-(triphenylmethyl)-1H-imidazol-4-yl]methanol | HCID 382182 | 87% |
반응 단계
7.98 g(59.2 mmol) of hydroxymethyl imidazole hydrochloride was dissolved in a solvent mixture of 60 ml of dimethylformamide and 20 ml of triethylamine. 200 ml of dimethylformamide solution containing 18.7 g (67 mmol) of triphenylmethyl chloride was added slowly thereto. After 2 hours, 1000 ml of ice water was added thereto to obtain a solid. This solid was recrystallized from dioxane to give 17.6 g of the title compound(Yield 87%, MW 340).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06384061B1 |
| 출처 데이터셋 | uspto-grants-2002_05 |
| ORD ID | ord-6a15fc1d300942609994586b81944e33 |
| 출처 메모 | uspto-grants-2002_05 |