Trifluoroacetic acid → HCID 178500641, compound

Participants

Reaction Steps

0.11 g(0.13 mmol) of 2-(2-{3-[3-(1-triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-yl}-acetylamino)-4-methylsulfanyl-butyric acid methyl ester prepared in Example 1-3) and 0.053 ml(0.26 mmol) of triisopropylsilane were dissolved in 5 ml of methylene chloride. Then, 5 ml of trifluoroacetic acid was added thereto and the resulting solution was stirred for one hour at room temperature. The organic solvent was removed under reduced pressure and saturated potassium carbonate[K2CO3] solution was added. The solution was extracted with 10 of ethyl acetate and the solvent was removed under reduced pressure. The residue was subjected to chromatography using a solvent mixture of methanol-methylene chloride(5:95) as the eluent to obtain 0.068 g(Yield: 95%) of the title compound.

Provenance & Evidence