HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 15434706, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Diphenylphosphinic chloride | HCID 73910 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 15434706 | HCID 15434706 | — |
Reaction Steps
N-(4-bromo-3-methyl-5-isoxazolyl)diphenyl phosphinic amide was prepared by the method of Example 3 with 4-bromo-3-methyl-5-amino isoxazole (0.18 g, 1.0 mmol), THF (5 ml), NaH (60% oil dispersion, 88 mg, 2.2 mmol), and diphenyl phosphinic chloride (0.23 ml, 1.2 mmol). Recrystallization three times from chloroform and hexanes provided 0.17 g (45%) of faint pink crystals, m.p. 178.5-181° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384261B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-cdd2575290f7480887c369e63213e247 |
| Source note | uspto-grants-2002_05 |