4-Methylmorpholine → HCID 10202344, compound

Participants

Reaction Steps

Isobutyl chloroformate (0.214 g, 1.57 mmol) and N-methylmorpholine (0.190 g, 1.88 mmol) were added to an ice cold solution of 0.336 g (1.57 mmol) of 4-(tert-butyl-dimethyl-silanyloxy)-2-butynoic acid in 15 mL of tetrahydrofuran under N2. After stirring for 30 min, it was transferred to an additional funnel plugged with a glass wool and added dropwise to a solution of 0.4 g (1.18 mmol) of 6-amino-4-[(3-bromophenyl)amino]-3-quinolinecarbonitrile in 3 mL of tetrahydrofuran and 1.5 ml of pyridine. The mixture was stirred at 25° C. for 1 h. The reaction solution was poured into ethyl acetate and washed with saturated sodium bicarbonate and brine. The product was collected and purified by flash column chromatography (60% ethyl acetate in hexane) to give 0.220 g of

Provenance & Evidence