反应详情

A mixture of 2-methyl-4-nitroaniline (38.0 g, 250 mmol), ethyl (ethoxymethylene)cyanoacetate (50.8 g, 300 mmol), and 200 ml of toluene was refluxed for 24 h, cooled, diluted with 1:1 ether-hexane, and filtered. The resulting white solid was washed with hexane-ether and dried to give 63.9 g, mp 180-210° C.

1. temperaturewas refluxed for 24 h
2. temperaturecooled
3. filtrationfiltered
4. washThe resulting white solid was washed with hexane-ether
5. customdried
6. customto give 63.9 g, mp 180-210° C.