3'-Aminoacetophenone → HCID 22466701, compound

HRID 1934980Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:17][CH2:18][CH2:19][O:20][CH3:21])[C:10]=2[O:12][CH2:13][CH2:14][O:15][CH3:16])[N:5]=[CH:4][C:3]=1[C:22]#[N:23].[CH3:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([NH2:33])[CH:28]=1)=[O:26]>>[C:25]([C:27]1[CH:28]=[C:29]([NH:33][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([O:17][CH2:18][CH2:19][O:20][CH3:21])[C:10]=3[O:12][CH2:13][CH2:14][O:15][CH3:16])[N:5]=[CH:4][C:3]=2[C:22]#[N:23])[CH:30]=[CH:31][CH:32]=1)(=[O:26])[CH3:24]

Participants

Reactant 2

HCID 74173'-Aminoacetophenone

HCID 22466727HCID 22466727, compound

Product 1

HCID 22466701HCID 22466701, compound

Procedure

In the manner of Example 116, 4-Chloro-5,6-bis(2-methoxyethoxy)-3-quinolinecarbonitrile was reacted with 3-aminoacetophenone to give the title compound; recrystallized from ethanol to give off-white solid, mp 250-253 (dec).

Sources & evidence

ORD record: ord-735bc506291345758aba6758ba32dc89
Source dataset: uspto-grants-2002_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06384051B1

Reaction notes

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