HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methylphenol → HCID 22466651, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methylphenol | HCID 17818 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-Chloro-8-methoxyquinoline-3-carbonitrile | HCID 22466699 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | HCID 22466651 | HCID 22466651 | 89.4% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Using an analogous procedure to that described in Example 274. A reaction mixture of 328.0 mg (1.5 mmol) of 4-chloro-8-methoxy -3-quinolinecarbonitrile, 173.3 mg (1.5 mmol) of pyridine hydrochloride and 203.2 mg (1.7 mmol) of 3-hydroxy-4-methyl-aniline in 15 mL of 2-ethoxyethanol was heated at 100° C. for 1.5 hr. After the work up, 407.7 mg (89.4%) of the product was obtained as a yellow solid, m.p. 148-150° C., mass spectrum (electrospray, m/e): M+H 306.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384051B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-a19e4bc9b07e409b92a17d00f08522d7 |
| Source note | uspto-grants-2002_05 |