HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methoxyphenol → HCID 22466565, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methoxyphenol | HCID 74314 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-Chloro-8-methoxyquinoline-3-carbonitrile | HCID 22466699 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | HCID 22466565 | HCID 22466565 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Using an analogous procedure to that described in Example 274. A reaction mixture of 200.0 mg (0.92 mmol) of 4-chloro-8-methoxy-3-quinolinecarbonitrile, 105.7 mg (0.92 mmol) of pyridine hydrochloride and 140.6 mg (1.0 mmol) of 5-amino-2-methoxy-phenol in 10 mL of 2-ethoxyethanol was heated at 100° C. for 2 hr. The work up gave 261.6 mg (89.0%) of the product as a deep yellow solid, m.p. 138-140° C. (dec.), mass spectrum (electrospray, m/e): M+H 321.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384051B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-db89b702bddc42bcb1eda2bc9209bbc4 |
| Source note | uspto-grants-2002_05 |