HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-fluoroaniline → 4-(4-Chloro-2-fluoro-phenylamino)-6-methoxy-quinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-Chloro-6-methoxy-quinoline-3-carbonitrile | HCID 22466763 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | 4-(4-Chloro-2-fluoro-phenylamino)-6-methoxy-quinoline-3-carbonitrile | HCID 22466602 | — |
Reaction Steps
The method of Example 281 was used with 218.6 mg (1 mmol) of 4-chloro-6-methoxy-3-quinolinecarbonitrile, 174.7 mg (1.2 mmol) of 4-chloro-2-fluoro-aniline and 115.6 mg (1 mmol ) of pyridine hydrochloride in 10 mL of 2-ethoxyethanol. This afforded 319.8 mg of the product as a yellow solid, m.p.>250° C., mass (electrospray, m/e): M+H 325.9, 327.9
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384051B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-24e585e7083e475c89e6429105cf96ad |
| Source note | uspto-grants-2002_05 |