HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 4-(4-Chloro-2-fluorophenylamino)-7-hydroxy-3-quinolinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile | HCID 22466662 | — |
| Product | 4-(4-Chloro-2-fluorophenylamino)-7-hydroxy-3-quinolinecarbonitrile | HCID 135670823 | — |
Reaction Steps
In the manner of Example 302 reaction of 4-(4-chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile with pyridine hydrochloride at 210° C. gave the title compound, mp 295-305° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384051B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-c28134586ff0484fa6fb31b387c13fda |
| Source note | uspto-grants-2002_05 |