HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methoxyphenol → HCID 22466669, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methoxyphenol | HCID 74314 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile | HCID 10586676 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | HCID 22466669 | HCID 22466669 | 89.3% |
Reaction Steps
Using an analogous procedure to that described in EXAMPLE 367, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 10 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 167.0 mg (1.2 mmol) of 5-amino-2-methoxyphenol to give 313.3 mg (89.3%) of the product as a gray solid, m.p. 254-256° C., mass (electrospray, m/e): M+H 351.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384051B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-8c6712c5e1484b8590ea646b6ab50c9a |
| Source note | uspto-grants-2002_05 |